All patients
PD-L1 < 1% PD-L1 > 1%
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
glioblastoma (GB), nivolumab based treatment vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results Checkmate 143, 2020 1.04 [0.83; 1.30]
1.04 [0.83 ; 1.30 ] Checkmate 143, 2020 1 0% 369 NA not evaluable progression or deaths (PFS)detailed results Checkmate 143, 2020 1.97 [1.57; 2.48]
1.97 [1.57 ; 2.48 ] Checkmate 143, 2020 1 0% 369 NA not evaluable objective responses (ORR)detailed results Checkmate 143, 2020 0.28 [0.14; 0.57]
0.28 [0.14 ; 0.57 ] Checkmate 143, 2020 1 0% 309 NA not evaluable TRAE (any grade)detailed results Checkmate 143, 2020 0.96 [0.63; 1.47]
0.96 [0.63 ; 1.47 ] Checkmate 143, 2020 1 0% 347 NA not evaluable TRAE (grade 3-4)detailed results Checkmate 143, 2020 1.24 [0.70; 2.19]
1.24 [0.70 ; 2.19 ] Checkmate 143, 2020 1 0% 347 NA not evaluable TRAE leading to death (grade 5)detailed results Checkmate 143, 2020 0.91 [0.02; 45.94]
0.91 [0.02 ; 45.94 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results Checkmate 143, 2020 0.91 [0.02; 45.94]
0.91 [0.02 ; 45.94 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Fatigue TRAE (grade 3-4)detailed results Checkmate 143, 2020 11.22 [0.62; 202.39]
11.22 [0.62 ; 202.39 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Headache TRAE (grade 3-4)detailed results Checkmate 143, 2020 3.66 [0.16; 81.65]
3.66 [0.16 ; 81.65 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Hypertension TRAE (grade 3-4)detailed results Checkmate 143, 2020 0.03 [0.00; 0.55]
0.03 [0.00 ; 0.55 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Increased ALT TRAE (grade 3-4)detailed results Checkmate 143, 2020 7.39 [0.39; 140.92]
7.39 [0.39 ; 140.92 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Increased lipase level TRAE (grade 3-4)detailed results Checkmate 143, 2020 7.39 [0.39; 140.92]
7.39 [0.39 ; 140.92 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Nausea TRAE (grade 3-4)detailed results Checkmate 143, 2020 0.91 [0.02; 45.94]
0.91 [0.02 ; 45.94 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Pneumonitis TRAE (grade 3-4)detailed results Checkmate 143, 2020 3.66 [0.16; 81.65]
3.66 [0.16 ; 81.65 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Pruritus TRAE (grade 3-4)detailed results Checkmate 143, 2020 0.91 [0.02; 45.94]
0.91 [0.02 ; 45.94 ] Checkmate 143, 2020 1 0% 347 NA not evaluable Rash TRAE (grade 3-4)detailed results Checkmate 143, 2020 0.91 [0.02; 45.94]
0.91 [0.02 ; 45.94 ] Checkmate 143, 2020 1 0% 347 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-06-08 20:31 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 61,202,203
- treatments: 855,360,719,721,720,842,642,674,1085,863