• metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) 5
• mNSCLC - L2 - adenocarcinoma cell
• mNSCLC - L2 - all population 5
• mNSCLC - L2 - EGFR high
• mNSCLC - L2 - EGFR mutant 1
• mNSCLC - L2 - EGFR wild type
• mNSCLC - L2 - KRAS mutant
• mNSCLC - L2 - KRAS wild type
• mNSCLC - L2 - PDL1 negative 1
• mNSCLC - L2 - PDL1 positive 7
• non squamous cell - mNSCLC - L2
• non squamous - mNSCLC - L2 - all population 1
• non squamous - mNSCLC - L2 - EGFR mutant
• non squamous - mNSCLC - L2 - PDL1 positive
• non squamous - mNSCLC - L2 - wild type (WT)
• squamous cell - mNSCLC - L2
• squamous - mNSCLC - L2 - all population 1
• squamous - mNSCLC - L2 - PDL1 positive

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab alone
• avelumab based treatment
• avelumab alone
• nivolumab based treatment
• nivolumab alone
• Tislelizumab

• versus all
• vs chemotherapy
• vs non platinum-based chemotherapy
• vs taxanes
• vs docetaxel

  All patients Age < 65y (younger) Age > 65y cell type, non squamous cell cell type, squamous cell ECOG 0 ECOG 1 EGFR mutant Gender, female Gender, male metastasis (brain) NO metastasis (brain) YES PD-L1 < 1% PD-L1 > 1% PDL1 (TC0 and IC0 : <1% of TC and IC) PDL1 (TC1/2/3 or IC1/2/3 : ≥1% of TC or IC) PDL1 (TC2/3 or IC2/3 : ≥5% of TC or IC) PDL1 (TC3 or IC3 : ≥50% of TC or ≥10% of IC ) smoker (current or former) smoker (never)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)   studies

mNSCLC - L2 - all population, anti-PD-(L)1 vs. all, meta-analysis of study results

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;