studies

laHNSCC - 1st line (L1), avelumab based treatment vs. all, meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsJAVELIN Head and Neck 100, 2021 1.31 [0.93; 1.85] 1.31[0.93; 1.85]JAVELIN Head and Neck 100, 202110%697NAnot evaluable progression or deaths (PFS)detailed resultsJAVELIN Head and Neck 100, 2021 1.21 [0.93; 1.57] 1.21[0.93; 1.57]JAVELIN Head and Neck 100, 202110%697NAnot evaluable objective responses (ORR)detailed resultsJAVELIN Head and Neck 100, 2021 0.95 [0.66; 1.36] 0.95[0.66; 1.36]JAVELIN Head and Neck 100, 202110%697NAnot evaluable AE (any grade)detailed resultsJAVELIN Head and Neck 100, 2021 0.67 [0.11; 4.05] 0.67[0.11; 4.05]JAVELIN Head and Neck 100, 202110%692NAnot evaluable AE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.54 [1.02; 2.33] 1.54[1.02; 2.33]JAVELIN Head and Neck 100, 202110%692NAnot evaluable STRAE (any grade)detailed resultsJAVELIN Head and Neck 100, 2021 1.19 [0.87; 1.64] 1.19[0.87; 1.64]JAVELIN Head and Neck 100, 202110%692NAnot evaluable TRAE (any grade)detailed resultsJAVELIN Head and Neck 100, 2021 0.67 [0.19; 2.40] 0.67[0.19; 2.40]JAVELIN Head and Neck 100, 202110%692NAnot evaluable TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.38 [0.97; 1.97] 1.38[0.97; 1.97]JAVELIN Head and Neck 100, 202110%692NAnot evaluable TRAE leading to death (grade 5)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97] 1.98[0.18; 21.97]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Abdominal pain TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76] 0.49[0.02; 14.76]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Acute kidney injury TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.24 [0.48; 3.19] 1.24[0.48; 3.19]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Adrenal insufficiency TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76] 0.49[0.02; 14.76]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Anaemia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.91 [0.58; 1.43] 0.91[0.58; 1.43]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Asthenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.50 [0.61; 3.72] 1.50[0.61; 3.72]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Blood creatinine increased TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.39 [0.44; 4.43] 1.39[0.44; 4.43]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Chills TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Colitis TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48] 0.25[0.01; 5.48]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Constipation TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Cough TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Decreased appetite TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.36 [0.71; 2.60] 1.36[0.71; 2.60]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Diarrhoea TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.99 [0.14; 7.06] 0.99[0.14; 7.06]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Dysgeusia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48] 0.25[0.01; 5.48]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Dysphonia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96] 0.99[0.02; 49.96]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Fatigue TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.16 [0.53; 2.54] 1.16[0.53; 2.54]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Febrile neutropenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08] 0.76[0.28; 2.08]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Headache TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Hypertension TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.99 [0.36; 10.93] 1.99[0.36; 10.93]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Hyperthyroidism TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97] 1.98[0.18; 21.97]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Hypothyroidism TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96] 0.99[0.02; 49.96]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Increase AST TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97] 1.98[0.18; 21.97]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Increased ALT TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 7.04 [0.86; 57.54] 7.04[0.86; 57.54]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Increased lipase level TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 5.00 [0.58; 43.02] 5.00[0.58; 43.02]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Infusion-related reactions TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 3.97 [0.18; 88.38] 3.97[0.18; 88.38]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Leucopenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.04 [0.55; 1.96] 1.04[0.55; 1.96]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Mucosal inflammation TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.11 [0.72; 1.72] 1.11[0.72; 1.72]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Nausea TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.30 [0.68; 2.49] 1.30[0.68; 2.49]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Nephritis TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Neutropenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.10 [0.73; 1.66] 1.10[0.73; 1.66]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Pancytopenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Peripheral neuropathy TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48] 0.25[0.01; 5.48]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Peripheral oedema TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76] 0.49[0.02; 14.76]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Pneumonia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08] 0.76[0.28; 2.08]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Pneumonitis TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 10.01 [0.55; 184.02] 10.01[0.55; 184.02]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Pyrexia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46] 0.49[0.04; 5.46]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Rash TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Sepsis TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46] 0.49[0.04; 5.46]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Stomatitis TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.99 [0.56; 1.74] 0.99[0.56; 1.74]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Thrombocytopenia TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 9.31 [3.63; 23.82] 9.31[3.63; 23.82]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Urticaria TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21] 1.98[0.07; 59.21]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Vomiting TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.88 [0.46; 1.70] 0.88[0.46; 1.70]JAVELIN Head and Neck 100, 202110%692NAnot evaluable Weight decreased TRAE (grade 3-4)detailed resultsJAVELIN Head and Neck 100, 2021 0.66 [0.34; 1.29] 0.66[0.34; 1.29]JAVELIN Head and Neck 100, 202110%692NAnot evaluable0.020.01.0relative treatment effectwww.metaEvidence.org2024-05-20 21:18 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 104 - treatments: 852,417,603,1051,876

- About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons