• metastatic/advanced - colorectal cancer (mCRC)
• mCRC - 1st line (L1) 1
• mCRC - 2nd line (L2) 3
• endometrial cancer 1
• esophageal cancer (EC)

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• pembrolizumab based treatment
• pembrolizumab alone

• versus all
• vs chemotherapy
• vs Standard of Care (SoC)

  All patients Age < 65y (younger) Age > 75y (older) Asian type BRAF mutant BRAF wild type ECOG 0 ECOG 1 Gender, female Gender, male RAS mutant RAS wild type

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)   studies

mCRC - 1st line (L1), anti-PD-(L)1 vs. all, meta-analysis of study results

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;