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esophageal cancer (EC), anti-PD-(L)1 , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

events or deaths (EFS) 0.63 [0.46, 0.86]< 10%1 study (1/-)99.8 %NAnot evaluable non important-

safety endpoints 00

AE (any grade) 1.81 [0.96, 3.41]< 10%1 study (1/-)3.3 %NAnot evaluable non important-
AE (grade 3-4) 1.10 [0.80, 1.51]< 10%1 study (1/-)27.9 %NAnot evaluable non important-
AE leading to treatment discontinuation (any grade) 1.76 [1.04, 2.97]< 10%1 study (1/-)1.7 %NAnot evaluable non important-
AE leading to treatment discontinuation (grade 3-4) 1.17 [0.64, 2.15]< 10%1 study (1/-)30.2 %NAnot evaluable non important-
SAE (any grade) 0.99 [0.71, 1.36]< 10%1 study (1/-)53.5 %NAnot evaluable non important-
SAE (grade 3-4) 0.98 [0.68, 1.42]< 10%1 study (1/-)53.6 %NAnot evaluable non important-
STRAE (any grade) 2.94 [1.30, 6.65]< 10%1 study (1/-)0.5 %NAnot evaluable non important-
STRAE (grade 3-4) 4.94 [1.49, 16.37]< 10%1 study (1/-)0.5 %NAnot evaluable non important-
TRAE (any grade) 2.86 [2.10, 3.88]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
TRAE (grade 3-4) 2.52 [1.41, 4.48]< 10%1 study (1/-)0.1 %NAnot evaluable non important-

TRAE (grade 3-4) endpoints 00

AE (grade 3-4) endpoints 00

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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