| Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
| deaths (OS) | 0.87 [0.74, 1.01] | | < 1 | | 46% | 4 studies (4/-) | 96.7 % | some concern | not evaluable | moderate | crucial | - |
| deaths (OS) (extension) | 0.68 [0.54, 0.86] | | < 1 | | 0% | 1 study (1/-) | 99.9 % | NA | not evaluable | | important | - |
| PFS (extension) | 0.87 [0.68, 1.11] | | < 1 | | 0% | 1 study (1/-) | 86.7 % | NA | not evaluable | | important | - |
| progression or deaths (PFS) | 1.00 [0.90, 1.10] | | < 1 | | 0% | 4 studies (4/-) | 53.0 % | some concern | not evaluable | moderate | important | - |
| DCR | 1.06 [0.77, 1.46] | | > 1 | | 0% | 2 studies (2/-) | 64.0 % | some concern | not evaluable | moderate | non important | - |
| objective responses (ORR) | 1.29 [0.94, 1.77] | | > 1 | | 26% | 4 studies (4/-) | 94.2 % | some concern | not evaluable | moderate | non important | - |
| objective responses (ORR) (extension) | 2.51 [1.07, 5.86] | | > 1 | | 0% | 1 study (1/-) | 98.3 % | NA | not evaluable | | non important | - |
safety endpoints 00 |
| AE (any grade) | 0.58 [0.33, 1.02] | | < 1 | | 6% | 2 studies (2/-) | 97.0 % | some concern | not evaluable | moderate | non important | - |
| AE (grade 3-4) | 1.09 [0.74, 1.61] | | < 1 | | 57% | 2 studies (2/-) | 33.4 % | some concern | not evaluable | moderate | non important | - |
| AE leading to death (grade 5) | 1.16 [0.74, 1.83] | | < 1 | | 0% | 2 studies (2/-) | 25.7 % | some concern | not evaluable | moderate | non important | - |
| AE leading to treatment discontinuation (any grade) | 1.24 [0.79, 1.96] | | < 1 | | 21% | 2 studies (2/-) | 17.6 % | some concern | not evaluable | moderate | non important | - |
| SAE (any grade) | 1.30 [0.98, 1.72] | | < 1 | | 0% | 2 studies (2/-) | 3.6 % | some concern | not evaluable | moderate | non important | - |
| STRAE (any grade) | 1.16 [0.56, 2.38] | | < 1 | | 0% | 1 study (1/-) | 34.4 % | NA | not evaluable | | non important | - |
| TRAE (any grade) | 0.32 [0.26, 0.40] | | < 1 | | 0% | 4 studies (4/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
| TRAE (grade 3-4) | 0.38 [0.22, 0.65] | | < 1 | | 74% | 3 studies (3/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
| TRAE leading to death (grade 5) | 2.26 [0.70, 7.25] | | < 1 | | 0% | 4 studies (4/-) | 8.6 % | some concern | not evaluable | moderate | non important | - |
| TRAE leading to discontinuation (any grade) | 0.86 [0.55, 1.32] | | < 1 | | 0% | 4 studies (4/-) | 75.9 % | some concern | not evaluable | moderate | non important | - |
| TRAE leading to discontinuation (grade 3-4) | 1.28 [0.53, 3.10] | | < 1 | | 0% | 1 study (1/-) | 29.1 % | NA | not evaluable | | non important | - |
TRAE (grade 3-4) endpoints 00 |
| Acute kidney injury TRAE (grade 3-4) | 0.67 [0.06, 7.40] | | < 1 | | 0% | 2 studies (2/-) | 62.8 % | some concern | not evaluable | moderate | non important | - |
| Adrenal insufficiency TRAE (grade 3-4) | 0.95 [0.07, 12.36] | | < 1 | | 0% | 2 studies (2/-) | 51.7 % | some concern | not evaluable | moderate | non important | - |
| Alopecia TRAE (grade 3-4) | 0.98 [0.10, 9.44] | | < 1 | | 0% | 3 studies (3/-) | 50.7 % | some concern | not evaluable | moderate | non important | - |
| Anaemia TRAE (grade 3-4) | 0.22 [0.10, 0.47] | | < 1 | | 0% | 4 studies (4/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
| Arthralgia TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Asthenia TRAE (grade 3-4) | 0.63 [0.18, 2.16] | | < 1 | | 26% | 4 studies (4/-) | 77.0 % | some concern | not evaluable | moderate | non important | - |
| Blood and lymphatic system disorders TRAE (grade 3-4) | 0.04 [0.01, 0.31] | | < 1 | | 0% | 1 study (1/-) | 99.9 % | NA | not evaluable | | non important | - |
| Blood creatinine increased TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Cardiac disorders TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Chills TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Colitis TRAE (grade 3-4) | 0.67 [0.04, 10.72] | | < 1 | | 0% | 2 studies (2/-) | 61.1 % | some concern | not evaluable | moderate | non important | - |
| Constipation TRAE (grade 3-4) | 0.47 [0.02, 14.21] | | < 1 | | 0% | 1 study (1/-) | 66.4 % | NA | not evaluable | | non important | - |
| Cough TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Decreased appetite TRAE (grade 3-4) | 0.58 [0.14, 2.36] | | < 1 | | 0% | 3 studies (3/-) | 77.7 % | some concern | not evaluable | moderate | non important | - |
| Dermatitis acneiform TRAE (grade 3-4) | 0.99 [0.06, 15.94] | | < 1 | | 0% | 2 studies (2/-) | 50.2 % | some concern | not evaluable | moderate | non important | - |
| Diarrhoea TRAE (grade 3-4) | 0.62 [0.14, 2.72] | | < 1 | | 33% | 4 studies (4/-) | 73.7 % | some concern | not evaluable | moderate | non important | - |
| Dyspepsia TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Dyspnoea TRAE (grade 3-4) | 3.83 [0.17, 85.33] | | < 1 | | 0% | 1 study (1/-) | 20.1 % | NA | not evaluable | | non important | - |
| Eczema TRAE (grade 3-4) | 0.47 [0.01, 23.80] | | < 1 | | 0% | 1 study (1/-) | 64.4 % | NA | not evaluable | | non important | - |
| Endocrine disorders TRAE (grade 3-4) | 1.34 [0.12, 14.83] | | < 1 | | 0% | 2 studies (2/-) | 40.7 % | some concern | not evaluable | moderate | non important | - |
| Epistaxis TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Erythema TRAE (grade 3-4) | 0.23 [0.01, 7.01] | | < 1 | | 0% | 1 study (1/-) | 79.5 % | NA | not evaluable | | non important | - |
| Eye disorders TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Fatigue TRAE (grade 3-4) | 1.18 [0.50, 2.75] | | < 1 | | 0% | 4 studies (4/-) | 35.3 % | some concern | not evaluable | moderate | non important | - |
| Febrile neutropenia TRAE (grade 3-4) | 0.05 [0.00, 0.79] | | < 1 | | 0% | 1 study (1/-) | 98.2 % | NA | not evaluable | | non important | - |
| Gastritis TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Gastrointestinal disorders TRAE (grade 3-4) | 0.33 [0.14, 0.77] | | < 1 | | 0% | 2 studies (2/-) | 99.5 % | some concern | not evaluable | moderate | non important | - |
| General disorders and administration site conditions TRAE (grade 3-4) | 0.57 [0.23, 1.40] | | < 1 | | 0% | 1 study (1/-) | 88.8 % | NA | not evaluable | | non important | - |
| Guillain-Barré syndrome TRAE (grade 3-4) | 1.91 [0.06, 57.09] | | < 1 | | 0% | 1 study (1/-) | 35.7 % | NA | not evaluable | | non important | - |
| Headache TRAE (grade 3-4) | 0.47 [0.02, 14.21] | | < 1 | | 0% | 1 study (1/-) | 66.4 % | NA | not evaluable | | non important | - |
| Hepatitis TRAE (grade 3-4) | 2.01 [0.07, 60.26] | | < 1 | | 0% | 1 study (1/-) | 34.6 % | NA | not evaluable | | non important | - |
| Hepatobiliary disorders TRAE (grade 3-4) | 0.94 [0.15, 5.84] | | < 1 | | 0% | 2 studies (2/-) | 52.4 % | some concern | not evaluable | moderate | non important | - |
| Hypersensitivity TRAE (grade 3-4) | 0.43 [0.03, 5.58] | | < 1 | | 0% | 2 studies (2/-) | 74.0 % | some concern | not evaluable | moderate | non important | - |
| Hypertension TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Hyperthyroidism TRAE (grade 3-4) | 0.67 [0.04, 10.72] | | < 1 | | 0% | 2 studies (2/-) | 61.1 % | some concern | not evaluable | moderate | non important | - |
| Hypophysitis TRAE (grade 3-4) | 0.94 [0.03, 28.25] | | < 1 | | 0% | 1 study (1/-) | 51.4 % | NA | not evaluable | | non important | - |
| Hypothyroidism TRAE (grade 3-4) | 1.02 [0.15, 6.73] | | < 1 | | 0% | 4 studies (4/-) | 49.1 % | some concern | not evaluable | moderate | non important | - |
| Increase AST TRAE (grade 3-4) | 0.35 [0.05, 2.48] | | < 1 | | 0% | 2 studies (2/-) | 85.3 % | some concern | not evaluable | moderate | non important | - |
| Increased ALT TRAE (grade 3-4) | 0.45 [0.10, 1.98] | | < 1 | | 0% | 4 studies (4/-) | 85.4 % | some concern | not evaluable | moderate | non important | - |
| Increased lipase level TRAE (grade 3-4) | 3.81 [0.20, 72.71] | | < 1 | | 0% | 1 study (1/-) | 19.0 % | NA | not evaluable | | non important | - |
| Infusion-related reactions TRAE (grade 3-4) | 0.54 [0.06, 4.66] | | < 1 | | 0% | 2 studies (2/-) | 71.0 % | some concern | not evaluable | moderate | non important | - |
| Leucopenia TRAE (grade 3-4) | 0.09 [0.02, 0.40] | | < 1 | | 0% | 4 studies (4/-) | 99.9 % | some concern | not evaluable | moderate | non important | - |
| Maculopapular rash TRAE (grade 3-4) | 0.47 [0.04, 6.17] | | < 1 | | 0% | 2 studies (2/-) | 71.5 % | some concern | not evaluable | moderate | non important | - |
| Metabolism and nutrition disorders TRAE (grade 3-4) | 0.40 [0.10, 1.57] | | < 1 | | 0% | 1 study (1/-) | 90.5 % | NA | not evaluable | | non important | - |
| Mucosal inflammation TRAE (grade 3-4) | 0.29 [0.06, 1.44] | | < 1 | | 0% | 3 studies (3/-) | 93.5 % | some concern | not evaluable | moderate | non important | - |
| Musculoskeletal and connective tissue disorders TRAE (grade 3-4) | 1.91 [0.06, 57.09] | | < 1 | | 0% | 1 study (1/-) | 35.7 % | NA | not evaluable | | non important | - |
| Myalgia TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Nausea TRAE (grade 3-4) | 0.67 [0.12, 3.87] | | < 1 | | 0% | 4 studies (4/-) | 67.3 % | some concern | not evaluable | moderate | non important | - |
| Nervous system disorders TRAE (grade 3-4) | 0.47 [0.04, 5.26] | | < 1 | | 0% | 1 study (1/-) | 72.7 % | NA | not evaluable | | non important | - |
| Neutropenia TRAE (grade 3-4) | 0.05 [0.01, 0.19] | | < 1 | | 0% | 3 studies (3/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
| Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4) | 0.43 [0.03, 5.58] | | < 1 | | 0% | 2 studies (2/-) | 74.0 % | some concern | not evaluable | moderate | non important | - |
| Pancytopenia TRAE (grade 3-4) | 0.16 [0.01, 3.15] | | < 1 | | 0% | 1 study (1/-) | 88.4 % | NA | not evaluable | | non important | - |
| Paraesthesia TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Peripheral neuropathy TRAE (grade 3-4) | 0.38 [0.06, 2.57] | | < 1 | | 0% | 2 studies (2/-) | 83.8 % | some concern | not evaluable | moderate | non important | - |
| Peripheral oedema TRAE (grade 3-4) | 1.91 [0.06, 57.09] | | < 1 | | 0% | 1 study (1/-) | 35.7 % | NA | not evaluable | | non important | - |
| Pneumonitis TRAE (grade 3-4) | 2.69 [0.30, 24.18] | | < 1 | | 0% | 2 studies (2/-) | 19.0 % | some concern | not evaluable | moderate | non important | - |
| Pruritic rash TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Pruritus generalised TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Pruritus TRAE (grade 3-4) | 0.51 [0.08, 3.20] | | < 1 | | 0% | 4 studies (4/-) | 76.2 % | some concern | not evaluable | moderate | non important | - |
| Pyrexia TRAE (grade 3-4) | 0.26 [0.02, 2.98] | | < 1 | | 0% | 2 studies (2/-) | 85.9 % | some concern | not evaluable | moderate | non important | - |
| Rash TRAE (grade 3-4) | 0.97 [0.14, 6.92] | | < 1 | | 0% | 3 studies (3/-) | 51.1 % | some concern | not evaluable | moderate | non important | - |
| Renal and urinary disorders TRAE (grade 3-4) | 1.05 [0.08, 13.66] | | < 1 | | 0% | 2 studies (2/-) | 48.7 % | some concern | not evaluable | moderate | non important | - |
| Respiratory, thoracic and mediastinal disorders TRAE (grade 3-4) | 1.50 [0.46, 4.88] | | < 1 | | 0% | 2 studies (2/-) | 25.3 % | some concern | not evaluable | moderate | non important | - |
| Sepsis TRAE (grade 3-4) | 0.24 [0.01, 5.27] | | < 1 | | 0% | 1 study (1/-) | 81.6 % | NA | not evaluable | | non important | - |
| Severe skin reaction TRAE (grade 3-4) | 0.54 [0.15, 1.86] | | < 1 | | 0% | 1 study (1/-) | 83.7 % | NA | not evaluable | | non important | - |
| Skin and subcutaneous tissue disorders TRAE (grade 3-4) | 0.27 [0.08, 0.89] | | < 1 | | 0% | 2 studies (2/-) | 98.4 % | some concern | not evaluable | moderate | non important | - |
| Skin exfoliation TRAE (grade 3-4) | 0.67 [0.04, 10.72] | | < 1 | | 0% | 2 studies (2/-) | 61.1 % | some concern | not evaluable | moderate | non important | - |
| Stevens-Johnson syndrome TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Stomatitis TRAE (grade 3-4) | 0.35 [0.04, 2.92] | | < 1 | | 34% | 3 studies (3/-) | 83.3 % | some concern | not evaluable | moderate | non important | - |
| Thrombocytopenia TRAE (grade 3-4) | 0.46 [0.10, 2.11] | | < 1 | | 17% | 4 studies (4/-) | 84.1 % | some concern | not evaluable | moderate | non important | - |
| Thyroiditis TRAE (grade 3-4) | 0.47 [0.01, 23.80] | | < 1 | | 0% | 1 study (1/-) | 64.4 % | NA | not evaluable | | non important | - |
| Urticaria TRAE (grade 3-4) | 0.47 [0.01, 23.80] | | < 1 | | 0% | 1 study (1/-) | 64.4 % | NA | not evaluable | | non important | - |
| Vascular disorders TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Weight decreased TRAE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
AE (grade 3-4) endpoints 00 |
| Back pain AE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Dizziness AE (grade 3-4) | 0.95 [0.02, 48.13] | | < 1 | | 0% | 1 study (1/-) | 51.0 % | NA | not evaluable | | non important | - |
| Rash AE (grade 3-4) | 0.23 [0.01, 7.01] | | < 1 | | 0% | 1 study (1/-) | 79.5 % | NA | not evaluable | | non important | - |
